Methods of measurement, statistical analysis and errors of measurement, method development and validation, the meaning of test results, accuracy, precision, analytical electrochemistry, biosensors, chemical separation, introduction to gas and liquid chromatography. Credit will be granted for only one of CHEM 211 or BIOC 211. [3-1-0] Prerequisite: One of CHEM 113, CHEM 123 and one of PHYS 121, PHYS 122.
Principles of thermodynamics and reaction kinetics in biochemistry. Acid/base biochemistry. Structure and function of lipids, amino acids, proteins, carbohydrates, nucleotides, and nucleic acids. Enzyme kinetics. Credit will only be granted for one of BIOC 304 or BIOL 311. [3-0-0] Prerequisite: One of CHEM 204, CHEM 214.
Metabolic pathways with a mechanistic perspective including regulation and control of carbohydrate, lipid, amino acid, and nucleotide catabolism and anabolism. Oxidative- and photo-phosphorylation. The biochemistry and molecular biology of signal transduction, replication, DNA repair, transcription, translation, and gene regulation. Credit will only be granted for one of BIOC 305 or BIOL 319. [3-0-0] Prerequisite: All of BIOC 304, BIOL 200.
Chemistry and biochemistry of winemaking (enology) and grape-growing (viticulture) including development of the important major constituents of a wine; ethanol, acids, sugars, and colour; the subtle aspects of the aroma; odour-active compounds and how they form; and the effects of storing a wine in oak barrels. [3-0-0] Prerequisite: One of CHEM 204, CHEM 214.
Principles of pharmacology, including pharmacokinetics and pharmacodynamics of drug action, pharmacology associated with the autonomic nervous system (sympathetic and parasympathetic branches), the neuromuscular junction, the inflammatory response, chronic obstructive pulmonary diseases, peptic ulcers, and general and local anesthesia. [3-0-0] Prerequisite: BIOL 200 and one of CHEM 204, CHEM 214.
Continuation of Pharmacology I. Expands on topics including pharmacokinetics and pharmacodynamics of drug action, interaction of drugs with the autonomic nervous system (ANS), the inflammatory response, and the treatment of chronic diseases. [3-0-0] Prerequisite: BIOC 308.
Chemical constituents of plants, their synthesis, their contribution to key metabolic processes, and the regulation of their biosynthesis. Synthesis of alkaloids, secondary metabolites, nutrients, and bioactive compounds. Discovery of new phytochemicals and human uses of plants. [3-0-0] Prerequisite: One of CHEM 204, CHEM 214 and one of BIOL 200, BIOL 210, BIOL 319, BIOC 305.
Topics include protein separation, enzyme kinetics, ELISA, DNA Ligation and Transformation, PCR, RFLP analysis, Agarose gel electrophoresis, STR and VNTR analysis, and gene regulation. Credit will be granted for only one of BIOC 393 or BIOL 393. [0-4-0] Prerequisite: BIOC 304 and one of BIOL 200, BIOL 228, CHEM 204, CHEM 214. Corequisite: BIOL 366. Equivalency: BIOL393
Structural components of proteins; classification by primary, secondary, and tertiary structure; protein chemistry and purification; peptide and protein synthesis by chemical means; and three-dimensional structure determination using X-ray diffraction and NMR. [3-0-0] Prerequisite: One of BIOC 304, BIOL 311.
Enzyme kinetics: steady-state kinetic analyses, fast-reaction methods, kinetic isotope effects. Catalytic mechanisms: coenzymology, radical-mediated reactions, catalytic rate enhancements. Special topics: enzyme evolution, multifunctional enzymes, biocatalysis, protein engineering. Credit will be granted for only one of BIOC 403, CHEM 403, CHEM 413, CHEM 569. [3-0-0] Prerequisite: One of BIOC 304, BIOL 311. Equivalency: CHEM403
Review of recent research on the structure, dynamics, and function of membranes, membrane lipids, and proteins. [3-0-0] Prerequisite: One of BIOC 304, BIOL 311.
Origin and Biosynthesis of natural products used as flavours, commodities, and medicines. New approaches to identification, elucidation, characterization, and production of natural products, including: biological chemistry, omics, metabolic engineering, and synthetic biology. Credit will be granted for only one of BIOC 406, CHEM 485 or CHEM 585. [3-0-0] Prerequisites: CHEM 204 or 214, and all of BIOC 310, CHEM 304, BIOL 319, BIOC 305.
Draws on foundational knowledge of normal biochemistry. Inborn errors of metabolism, abnormal growth and metabolism, neurodegeneration and inappropriate protein folding, deficiency diseases, endocrine disorders, and cardiovascular and hematological disorders. Credit will be granted for only one of BIOC 407 or BIOL 507. [3-0-0] Prerequisite: One of BIOC 305, BIOL 319.
Chemical, physical, and biological properties of nucleic acids and their role in replication, transcription, translation, and regulation of expression of genetic material. [3-0-0] Prerequisite: BIOL 366.
Chemical analysis of the metabolites in biological samples: study design, sample extractions, method development and validation, targeted and untargeted experiments, data processing, isotope tracer studies, chemoinformatics, compound identification, metabolic pathway and network mapping, data interpretation and presentation. Credit will be granted for only one of BIOC 412, CHEM 412 or CHEM 533. [3-0-0] Prerequisite: One of CHEM 211, BIOC 211. and fourth-year standing in Biochemistry.
Advanced or specialized biochemistry topic. Seminar presentation required using original literature in the field. Repeatable for up to 9 credits with different topics. [3-0-1] Prerequisite: Third-year standing in any B.Sc. program and permission of the department head.
Biotechnological application of enzymes and whole cell catalysts for the synthesis of biofuels, pharmaceuticals, and other fine chemicals. Emphasis on enzymes used for organic synthesis, protein and metabolic engineering, and immobilization strategies. Credit will be granted for only one of BIOC 425 or CHEM 591. [3-0-0] Prerequisite: One of BIOC 304, BIOL 311.
Library (3 credits) or laboratory project with written report (3 or 6 credits) allowing a student to undertake an investigation on a specific topic as agreed upon by the faculty and student. Prerequisite: Fourth-year standing in the Major in Biochemistry and Molecular Biology program with a minimum overall grade average of 72%, and permission of the supervisor's department. The credit value for this course will be determined in consultation with the student prior to the registration.
Original research work under the direction of a faculty member. A written thesis with a public presentation of the thesis in the form of a poster or a seminar is required. Prerequisite: Fourth-year standing in the Major in Biochemistry and Molecular Biology program with a minimum overall grade average of 76%, a research project, and permission of the supervisor's department.
Examination of the biophysical principles underpinning various molecular and cellular processes. Statistical mechanics, biophysics of macromolecules, DNA mechanics, and more. Tools and techniques at the vanguard of nanoscience and nano-biotechnology, such as single-molecule fluorescence, super-resolution microscopy, and DNA sequencing. Credit will be granted for only one of BIOC 477, CHEM 477 or CHEM 577. [3-0-0]
Current techniques in DNA manipulation and analysis will be presented, relevant to such areas as molecular biology, microbiology, and biochemistry. Topics include site- directed mutagenesis, variations in cloning techniques, sequence analysis, Southern blotting, plus maintenance of a research lab notebook. [0-4-0] Prerequisite: One of BIOC 393, BIOL 393. BIOL 366 is strongly recommended.
Current methods in gene expression will be presented, relevant to such areas as molecular biology, microbiology, and biochemistry. Topics include extraction, handling and manipulation of RNA, analysis of gene expression (transcriptional), production of recombinant proteins, and genetic transformation of eukaryotes. [0-4-0] Prerequisite: BIOL 366 and one of BIOC 393, BIOL 393.
Course designed to enhance oral and written communication of scientific concepts. Each student will present two seminars and write an NSERC-style grant related to their research. Credit will be granted for only one of BIOC 530 or BIOC 630. Prerequisite: Admission to the Biochemistry and Molecular Biology graduate program.
Pass/Fail.
Pass/Fail.